Hewlett Packard Enterprise 781516-B21 Hard Disk Drive

The Hewlett Packard Enterprise 781516-B21 is a 600GB 12G SAS 10K SFF hard disk drive designed for enterprise servers and storage arrays, delivering fast, reliable data access in HPE ProLiant Gen9/Gen10 environments. This 2.5-inch small-form-factor drive uses SAS 12Gb/s, spins at 10,000 RPM, and arrives in a Smart Carrier (SC) with hot-swap capability to minimize downtime during maintenance. It’s commonly deployed for transactional systems, databases, virtualization workloads, and other business-critical applications requiring consistent throughput and low latency. Common replacements include HPE 872479-B21 (600GB SAS 12G 10K SFF HDD), HPE 507127-B21 (600GB SAS 6G 10K SFF HDD), and HPE 652583-B21 (600GB SAS 6G 15K SFF HDD).